	   SnapGene      egcggtgcaaatgtgttttacagcgtgatggagcagatgaagatgctcgacacgctgcagaacacgcagctagattaaccctagaaagataatcatattgtgacgtacgttaaagataatcatgtgtaaaattgacgcatgtgttttatcggtctgtatatcgaggtttatttattaatttgaatagatattaagttttattatatttacacttacatactaataataaattcaacaaacaatttatttatgtttatttatttattaaaaaaaacaaaaactcaaaatttcttctataaagtaacaaaacttttatgagggacagcccccccccaaagcccccagggatgtaattacgtccctcccccgctagggggcagcagcgagccgcccggggctccgctccggtccggcgctccccccgcatccccgagccggcagcgtgcggggacagcccgggcacggggaaggtggcacgggatcgctttcctctgaacgcttctcgctgctctttgagcctgcagacacctggggggatacggggaaaaggcctccacggccactagtttcactcgagtttactccctatcagtgatagagaacgtatgaagagtttactccctatcagtgatagagaacgtatgcagactttactccctatcagtgatagagaacgtataaggagtttactccctatcagtgatagagaacgtatgaccagtttactccctatcagtgatagagaacgtatctacagtttactccctatcagtgatagagaacgtatatccagtttactccctatcagtgatagagaacgtatgtcgaggtaggcgtgtacggtgggcgcctataaaagcagagctcgtttagtgaaccgtcagatcgcctggagcaattccacaacacttttgtcttatacttggtacctatgcatgccaccatgagcatccagaagtccaccaacagcagcagcctggccgaagtgatcgaccggatcctggacaagggcatcgtgatcgacgccttcgccagagtgtccgtcgtgggcatcgagatcctgaccatcgaggccagagtcgtgatcgccagcgtggacacctggctgagatatgccgaagccgtgggcctgctgcgggacgacgtggaagaaaatggcctgcccgagcggagcaacagctctgagggacagccccggttcagcatctgaactaaatcgcactgtcggcgtccccccctaacgttactggccgaagccgcttggaataaggccggtgtgcgtttgtctatatgttattttccaccatattgccgtcttttggcaatgtgagggcccggaaacctggccctgtcttcttgacgagcattcctaggggtctttcccctctcgccaaaggaatgcaaggtctgttgaatgtcgtgaaggaagcagttcctctggaagcttcttgaagacaaacaacgtctgtagcgaccctttgcaggcagcggaaccccccacctggcgacaggtgcctctgcggccaaaagccacgtgtataagatacacctgcaaaggcggcacaaccccagtgccacgttgtgagttggatagttgtggaaagagtcaaatggctctcctcaagcgtattcaacaaggggctgaaggatgcccagaaggtaccccattgtatgggatctgatctggggcctcggtgcacatgctttacatgtgtttagtcgaggttaaaaaacgtctaggccccccgaaccacggggacgtggttttcctttgaaaaacacgatgataatatggccacaaccatggtgagcaagggcgaggaggataacatggccatcatcaaggagttcatgcgcttcaaggtgcacatggagggctccgtgaacggccacgagttcgagatcgagggcgagggcgagggccgcccctacgagggcacccagaccgccaagctgaaggtgaccaagggcggccccctgcccttcgcctgggacatcctgtcccctcagttcatgtacggctccaaggcctacgtgaagcaccccgccgacatccccgactacttgaagctgtccttccccgagggcttcaagtgggagcgcgtgatgaacttcgaggacggcggcgtggtgaccgtgacccaggactcctccctgcaggacggcgagttcatctacaaggtgaagctgcgcggcaccaacttcccctccgacggccccgtaatgcagaagaagaccatgggctgggaggcctcctccgagcggatgtaccccgaggacggcgccctgaagggcgagatcaagcagaggctgaagctgaaggacggcggccactacgacgctgaggtcaagaccacctacaaggccaagaagcccgtgcagctgcccggcgcctacaacgtcaacatcaagttggacatcacctcccacaacgaggactacaccatcgtggaacagtacgaacgcgccgagggccgccactccaccggcggcatggacgagctgtacaagtgaactagttcgttaactaaacttgtttattgcagcttataatggttacaaataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgcattctagttgtggtttgtccaaactcatcaatgtatcttatcatgtctggaattgactcaaatgatgtcaattagtctatcagaagctcatctggtctcccttccgggggacaagacatccctgtttaatatttaaacagcagtgttcccaaactgggttcttatatcccttgctctggtcaaccaggttgcagggtttcctgtcctcacaggaacgaagtccctaaagaaacagtggcagccaggtttagccccggaattgactggattccttttttagggcccattggtatggctttttccccgtatccccccaggtgtctgcaggctcaaagagcagcgagaagcgttcagaggaaagcgatcccgtgccaccttccccgtgcccgggctgtccccgcacgctgccggctcggggatgcggggggagcgccggaccggagcggagccccgggcggctcgctgctgccccctagcgggggagggacgtaattacatccctgggggctttgggggggggctgtccctgatatctataacaagaaaatatatatataataagttatcacgtaagtagaacatgaaataacaatataattatcgtatgagttaaatcttaaaagtcacgtaaaagataatcatgcgtcattttgactcacgcggtcgttatagttcaaaatcagtgacacttaccgcattgacaagcacgcctcacgggagctccaagcggcgactgagatgtcctaaatgcacagcgacggattcgcgctatttagaaagagagagcaatatttcaagaatgcatgcgtcaattttacgcagactatctttctagggttaatctagctgcatcaggatcatatcgtcgggtcttttttccggctcagtcatcgcccaagctggcgctatctgggcatcggggaggaagaagcccgtgccttttcccgcgaggttgaagcggcatggaaagagtttgccgaggatgactgctgctgcattgacgttgagcgaaaacgcacgtttaccatgatgattcgggaaggtgtggccatgcacgcctttaacggtgaactgttcgttcaggccacctgggataccagttcgtcgcggcttttccggacacagttccggatggtcagcccgaagcgcatcagcaacccgaacaataccggcgacagccggaactgccgtgccggtgtgcagattaatgacagcggtgcggcgctgggatattacgtcagcgaggacgggtatcctggctggatgccgcagaaatggacatggataccccgtgagttacccggcgggcgcgcttggcgtaatcatggtcatagctgtttcctgtgtgaaattgttatccgctcacaattccacacaacatacgagccggaagcataaagtgtaaagcctggggtgcctaatgagtgagctaactcacattaattgcgttgcgctcactgcccgctttccagtcgggaaacctgtcgtgccagctgcattaatgaatcggccaacgcgcggggagaggcggtttgcgtattgggcgctcttccgcttcctcgctcactgactcgctgcgctcggtcgttcggctgcggcgagcggtatcagctcactcaaaggcggtaatacggttatccacagaatcaggggataacgcaggaaagaacatgtgagcaaaaggccagcaaaaggccaggaaccgtaaaaaggccgcgttgctggcgtttttccataggctccgcccccctgacgagcatcacaaaaatcgacgctcaagtcagaggtggcgaaacccgacaggactataaagataccaggcgtttccccctggaagctccctcgtgcgctctcctgttccgaccctgccgcttaccggatacctgtccgcctttctcccttcgggaagcgtggcgctttctcatagctcacgctgtaggtatctcagttcggtgtaggtcgttcgctccaagctgggctgtgtgcacgaaccccccgttcagcccgaccgctgcgccttatccggtaactatcgtcttgagtccaacccggtaagacacgacttatcgccactggcagcagccactggtaacaggattagcagagcgaggtatgtaggcggtgctacagagttcttgaagtggtggcctaactacggctacactagaagaacagtatttggtatctgcgctctgctgaagccagttaccttcggaaaaagagttggtagctcttgatccggcaaacaaaccaccgctggtagcggtggtttttttgtttgcaagcagcagattacgcgcagaaaaaaaggatctcaagaagatcctttgatcttttctacggggtctgacgctcagtggaacgaaaactcacgttaagggattttggtcatgagattatcaaaaaggatcttcacctagatccttttaaattaaaaatgaagttttaaatcaatctaaagtatatatgagtaaacttggtctgacagttaccaatgcttaatcagtgaggcacctatctcagcgatctgtctatttcgttcatccatagttgcctgactccccgtcgtgtagataactacgatacgggagggcttaccatctggccccagtgctgcaatgataccgcgagacccacgctcaccggctccagatttatcagcaataaaccagccagccggaagggccgagcgcagaagtggtcctgcaactttatccgcctccatccagtctattaattgttgccgggaagctagagtaagtagttcgccagttaatagtttgcgcaacgttgttgccattgctacaggcatcgtggtgtcacgctcgtcgtttggtatggcttcattcagctccggttcccaacgatcaaggcgagttacatgatcccccatgttgtgcaaaaaagcggttagctccttcggtcctccgatcgttgtcagaagtaagttggccgcagtgttatcactcatggttatggcagcactgcataattctcttactgtcatgccatccgtaagatgcttttctgtgactggtgagtactcaaccaagtcattctgagaatagtgtatgcggcgaccgagttgctcttgcccggcgtcaatacgggataataccgcgccacatagcagaactttaaaagtgctcatcattggaaaacgttcttcggggcgaaaactctcaaggatcttaccgctgttgagatccagttcgatgtaacccactcgtgcacccaactgatcttcagcatcttttactttcaccagcgtttctgggtgagcaaaaacaggaaggcaaaatgccgcaaaaaagggaataagggcgacacggaaatgttgaatactcatactcttcctttttcaatattattgaagcatttatcagggttattgtctcatgagcggatacatatttgaatgtatttagaaaaataaacaaataggggttccgcgcacatttccccgaaaagtgccacctaaattgtaagcgttaatattttgttaaaattcgcgttaaatttttgttaaatcagctcattttttaaccaataggccgaaatcggcaaaatcccttataaatcaaaagaatagaccgagatagggttgagtgttgttccagtttggaacaagagtccactattaaagaacgtggactccaacgtcaaagggcgaaaaaccgtctatcagggcgatggcccactacgtgaaccatcaccctaatcaagttttttggggtcgaggtgccgtaaagcactaaatcggaaccctaaagggagcccccgatttagagcttgacggggaaagccggcgaacgtggcgagaaaggaagggaagaaagcgaaaggagcgggcgctagggcgctggcaagtgtagcggtcacgctgcgcgtaaccaccacacccgccgcgcttaatgcgccgctacagggcgcgtcccattcgccattcaggctgcgcaactgttgggaagggcgatcggtgcgggcctcttcgctattacgccagctggcgaaagggggatgtgctgcaaggcgattaagttgggtaacgccagggttttcccagtcacgacgttgtaaaacgacggccagtgagcgcgcctcgttcattcacgtttttgaacccgtggaggacgggcagactc  :Ë   (   &      *      '                     2         '   #         "   1   !      #                              %                  	         %                  %   !      %   '            +         (   !   %          (               '            
   *      %   %         ,   !      (   -   >   "                                                                     )               "                                                         "                                                 '                  &                           
       !         )   2               !               #   !                              *             (   )            "                  +             #   +   #   "                                  $         $                              !      $   $             "             "            (      #   @        ( stˆ½Î[d”Ùœ
�
ÑÙÚÛ)*234567Éµ"¤X”¦Çâã& =W¾ÏÜo ˆÚÅ.Äž
ÒÜþÊ?uýõ#¥¢}MìW$ï	(°ä \Î
ô
u–¶Yþl§DÈþ	* u‰ÈKïd1e•Qrx~�®#¿ò¦	J·÷+8ÂL8êQ­•,†š<DŠµÂZ  ¨z�3N/ÅÝêïÿË$Nð7S' Ðyí7r�žÐ=‘	c
2–Î÷@ÏŸö°Õ[£Øi©í†%5Zä
$)± XÝâ3m‰Ö<Ó*‰vœþ 5¦ˆa8~™X¥å >¿éFp¡ÛÆD_nã	m	‚	¾	Ÿ
å�/=vV  ÔHøåœE¥PƒoD\Ýò·,Ò{‘2ÿÏ½ ;›ySv‹Å5Zp·äEÿ £ «ºáù	>
Ï
í
õ
'vé,“Z�Îm¨E
 • •]{(	�
ä
È— aaØZ…á¾œÉW2 š?LÉÞsy¯HKrçó	S	¶	ø¸Å÷IMV)9oˆî/N«xj6L–-‡›=E‹¶Ûò v³É×ð'ÊŽ�¹	ÃòMó *ÔK[ ŠNKfRâ$À	Xy¸Ìû,9£‡iüëŸR‡J¡' #,Ñ.eƒßô2?ð–Ê '^²ê¥È	:	§	KImÅÐâ”^®¹¡Ã)# ¡ ;9,ž/¸Opv|‹!BÆá	&	€	¤	”Ìç'*nþOÍT TxœÀä,Rjöˆ>@%‹w'µ> =a©	3.B4du‘ü@Á*„ß×õm=Ia"  ®\{°Œ‘P0ÒÂ	�Þëð B šÅr½j²{ñÿ801 % Ñ^¹Õ\zãŒ�Ÿ©jv¢ó†³¶ï		@	…
ŠÏÒíA© \¤Œ©ÈAºª¹î¯_%*²! R }8>ì—Qy:ø$*v÷±2Ù0n‡™6–¼Š -3Þ ´ îsƒd
3Pž)&>‹5# : ìVzžÂæ
.i·ÑÒZ;’	›	Ï	s_»ÐµÖ÷¬jo[p­åK  " ( Ynõ8×r
Ô7�!ýÁžæ V q ¹ Pt˜¼à(T4øC¬wÿ6§G‰?HoY€@ G =+:åb%�Žùõ ÞrÚãø:Š�lø�Šî9DLš¦dv¤¦·Û¹ d „ üqtMÜEo¢ä	 	¿	'
_&W / ?À
êG¢¬áÇ n	 
¥
ßî‘Èì09:æ0 …	`ƒ	i
8¿hS>?/
w_ ÊÞ%¿–¨SY¹.	æx	y9: ÕIDbw;ß,N�	<
G-©�’g¼0tQ%  b Nr–ºÞ&gØö8-Š,X¦ñ6QW„Í	Ý]>tÃ»ü «.  z ‹ Bùý®Á
pEÞrªÓï:3À.KP  ¹ûæ"�FG	£±ÙØàó¸gñ|eƒzÏÁÐ¾é <ºpÂÕuå<ûR | +\«l¦Y¬ŒÛ6[Ù÷²ùÄÏÕd  š Z~¢Æê2ÿY„S
Td�3wÆq±¸ÏF0�	 g DœzÞÚ—	Ç	 €)08j	9
î
êÚèá(æ€¨¶?²;FM­û k Ù»Ù	ú	d“ÌwB|”Ïxêo�ÂÏnÕàì÷%  � ¤ Á ú 4?c«Ïóbÿ°âæ	?
®
ö
(þ.k-ñQ½AøVÀE ¬–6fØwÕ	Ã
Ð
�Òdh~—esÎÜ †þ[�½©P; 65Æ‡µÉ“‚òþbÙ7>Ê nD)	_	u
å
¡·Z©¡b&†5«íO€X – � E^|¶Å_
}
‘
r˜%[âÛt’ d–¼ÌÏC
ý
¼=�,¿�c�%   »mŽÎî°IŽÔ	·	×íùÆ	ð…ðõJ *mt‰y	�4}:UÀ! }½ßtzsô†›%å"Æp0luk7—.ˆœ1·Üó  ·@BÊýW4L�µXWØ1æïO§MöÓêbŽ% ›M<2ŒèT	Ÿ	à0¹¬øNPÝ:[i¬¾+´b®>F`vŒ¥24'  7 @ wz´‚YÇÊ“ÇËk°þI	í	¾
ñ
 vƒeâ'­NQg"-¶½Õl\  }“(w
D´¿Êôj—Ä…L§î ‡ ¦¤²ñ±Rº	
#
1
éTƒÄó®£
+Ýãb ÊØÁŸH�ö‘Âó *OóØÑ°Ú+ 4 ÷OjgŸ‰Á	
	#	L	Ä	¹Æ :€µúhXjë¿çìÅg¯H]¢Øë C o2»Ç~ ñ$@„Ì âðé¢¥>%ð	Y-ˆRêD�®óSK x( + ‹��ú^™LSãˆ
ß
zÍü¤ƒß<L]}ý _k¹àÀèb€ˆ:U”B| ! �°ÒY_àæõ€ý¡	¨	ÉâÌÕÚ$œã~¦¯éºÒs�% -¨/>lñø$(_š	;	«	#¥JnÆÑGTË¢òdÃ™Ô* $OvÍÿf„è—ÁëÉV	÷ÛS±º”•+ÐÄ6  CP„Äˆ¦3@qËƒ³º¦êC	O	-L³ò¯Õ¥æ_H¢ó( <VrîŸ0ZcPqw}Œ­"ñ¥	ó
It£|P¬#+k¥C…™î'C‰´á §qŽl2C^mâ	�	•ˆÍ¯Ô<`7˜¤#6U ¢ Ó:zäx¹D¤‚'	ì
&nèC+Ä×oÎ ">-óÉÉéÇ	9	xl(‡ÄÏáûMwÿ)i ñ S`w›¿ã+[2A 	€“=?Aû&)iƒÞô`þ' 9 Q Uy�Áå	-¸|u²µ?	„
‰Pr9OÑ)�´¨«/@¸®(n•4o, ! ' F U p ¸ qSk÷«äF$CŒ¥>�ü¶? 	„«•¸-	¤
g9x9^ Mq•¹Ý%f×
!+Ì	À
Ü©ÂŽfûd»¿-yÀJO-
 *–	o°ÎØöú±* À 3>bªÎò•/75e×vi	Ô	8
c’Ñý}–AÍ…Îà¼é'ýnµ>¼U¿ú »4C´|
 ¨ñ%+Úb%  |¶A�¼ÍV1Ó…Œšßì$ï!«ï
s¦k³Œõ|Ò09T1%  yX|±ÆÉ’°Q’õý

"
½
‚òC³¢¾ÉPf!–×kâaÙ B ]˜¡žˆ		K	Ã	ï	‡
´gÆ|^¸æçðT“ÿ × BO€¯ÃÌ^¥å÷B	",ñÔ¤Ë›°SÊ¡¥ò, Ò!¦íòpy�bkw1C£¬è�ð	8	B†ÃÎà6{—«h£"*„í"&5³àð! & T o _{ª@´·,	>	£
Oª<NÐú³E8ªÝ?Bû3_n+ ¿ )ºÖ*h	Ë	bnŸ¨$�»Íºù°´x¿¾Nù( NW]ä‘ öU�ô‡ü	A	
!
†
‹™ñ³Óîª¡¯]¥åÉï‹`ÑØ/- S n (M Voõ?
 
~˜ž©;ù§®…²ÂÍßDÜ5–ÌŠw!¾2mƒ×ì!.4ß> ~ 	
0U~ô¾¿ÀíîR�¨Ö%ÁÌÝÞÚÛ1234o”•´µ‡ˆ‰vˆš —˜½ã 1‹Œ!"   â ¼Gÿ	

n
Sz–×+w¯¶Â7™¡Êäïú!,ß ë 19¯Áïà	G
¹
É
&ø3öúpÛœ‰›��"  €*t„H­ö	P
o
Qé,¾·ðl8Œ| µ Ü ß ïû 


²
T_{�F¿Ž™	*R\'?Vš¢Ø6 € ¯ ã ï ^
e
x
4†]x‰Ô°âáËåð Y t ½—¯Øz[ŸÃÇ÷û"-ºà íW{ŸÃç/Ö³Â[\	}	œ	'YªkaŠq}# ; è ì -‡Ã•°_ð"b	“	º
Lt~¼“¶]­÷	ž\ 2¸<–Ð	Ü	á	H
Ê
`ÑÊ™qÜBÆpœ×© K j:ÒÓè
¶ù×4ø0û�ÆŽ®æfL  �I†þ
%L½¼	÷	Võž-3_HÌÒŸ # 9\È®ö9p
w�	58ê¿‰¸Õmty 	 x ‰ ø Z4	+…¬ÜØQ
]
s
¹s~Â9�ç ) €¢¦Wuo£:®Õ³RVM"ñðþ2} ¶ Qu™½á)5	
Ïeù¶%
+i£7A W r Ý à &¤Sðù ô	

J]`|„­¥¨B@šßZ(›* ] œ º É Uü³
Ö
DUWY[‚GŽ ÑÓW…Ù × •xÀ7–�HŠIpS]@F� _ � �ê	f
5PëyÕ5ã!ƒ\qÌ H ¬ ¼ Æ _y
‡æÑc&Ž±ßYjÏö ¨ ° Ë ð ô þ 
%
µ
º5I^³€�d‡‘´Ûñú ä €T[3
>,;ŠPâ"æ•œ? ’ ž ßsÛóù);¾mŒ	Š�¬Æ"D-¥áº) Z u Jn’¶Úþ"+.ùe	q	
M
Z
�
g°Ù…‹°\y ‘Äø“eÅ€hü.–²» ì³‹�{U
Œ
F˜l{¾Èº:M›ÈZ§Üå ¨´ä Ê¨
Ø
fž#—ïE§!ÌÖwõ¸# ÌÚ*F×\àFp£å	ü(Z‘�VKU3'X rNób‰	~	™	À		˜õ=lFb$" e i bX| Äè0u×´û'ÃÝï]	j¤,v‹r~©C 2 > … îý!	�	ÄÄõc(Q«½)`~8[Ò  @ÁðÄ–£â”	»
"”Éí›:^�®ç'
‡ é í .…ë­±`6	Z	{	É	ý	

¡
Mï½‡‘øŸ] Õ ¡ª#JÈc	o	¦
!u1”Ï·rgƒ² 0 < Ï ˆHñ‡	à’�;£1m ÃÜ.
Ë
9aÒãPJWÚêØª Ù 0¹
	„	Ñ	Ý	i?š¥Cg¦Ü Ñ 3†Š—=—â	â@ÝÇqì 9Cg‹¯Ó÷a®	I
j
ÀËT�r0È�ËBHx` kß—T³	çæÂØ…
ÿr„:_¬;� Ë«À&Ô©“º/	‰	é
2zJüíWžò¯gj žJ;Ú
2	t	¨qúŒÒ¡Æ L ÀÓ|‘øZÜ·9E5yù1zÇÓµçoM Jc‡“Ä-¾ÃÍ
(1Átü´7éýÆ¯ý  yèExì�2<Ml	�	½	b
;ö.4Zh…YuR šàOø	=
�
ã
RŸ`Y�¶ã„à½1DÍ ÖÐM‚Þ&>ÝJÿ&W·HUí.ªL“]I¸Ó JÚ : ¯Q�.-%	�?ÀÄ¼)ŠÖý&´zH/" $ ³ ë]h¶‚‹¨iëY¡ò:…î		Î	xì^u‹Ç¹=^Š¬J  Os—»ß'Ù÷9Ž÷7q
B69íKnuÚ c ƒ É$L§RXh
7¾Þí
ëR	^å.	 
 a y Š ú,+:­;
Fßqsºîð‚è { ™ [C¹þƒÝÙÆ	R
«ÁÔt;/ÃŽÎQ  Œ ù 
¯å	­
Â
cj{råÁ±:ßöLO¬ 5�ÅD†ÎB
^
t
ü
q»<ý�4ªìs ºlüí;‹Ö´Wô×Ü0Zlh½3_~¤¿   6 �£vÆžGj¯H	ì	0
ð
uS‚Ná	òiÃ„ÜÐí * ùi¤Þ
ê}Äòf#ÿA{ê §X‡ç#p¹N	¤²ÈÚÔÙ#¹å}*èñGÂÑ q=YÈHsúÃÖv¤BB E P · Rvš¾â*q8§¤=ó”8ý 2e6³Ó	7
{
Ð&ü, »

+~f·eæ’jS ¾ ¥ñam7zø³ú)Ðø' m } á 'T»½ß	

¸
•œ§¦­ÜC®³ÁËÚ›uœÉâîù+lÖÞë  X s ® Û Þ ]ú¬õ	±
^…®yèZ½Ó�öáà[×¹{ J ,Õ!Û	K}XÉ©\˜AÅ
e ÷ 8[Ç3¡V…ýUŽrÔGÑ1 › È %£R” ó	Õ
IVXZ\ƒÎAÐÒ) ^ § « » Å Ê ó ý Zé	´
4H4²ÞX[p†�ÚiÎ& ‘ � Im‘µÙëý!T
Y
€
×
eEf‰k�½~x–Ç!C¹�’ËÄg• h aEˆßî	˜	b—�œ(UEJT¨Ñ  Î Ô ï©~5	Y	†	È	ü	 €¢&q‚† Ø BfŠ®Òö–ÛéëAG �{Ûå1yÁ8DI„‹ÑìVq^« ™ë%1k	Q0T6µâƒßC·„XÅ®ü ‚ ² ÿK�§êg
6½ìë(ŠìJ³<]‰GI ` Ž*9‚ä	:
A
zä�©rÍÞõN Åë	Ý
ï
 ÖÛ/é)ç"@F
 d²z
*G7d‘“ü  I l ­ ½ ¼Ú	°
·
”›xWçÒy­²ÀõàtÖáíø	kz÷! � ¦ ª Ä Ç ò ö ü  7“è	ò	X
Ô
eˆÍ}•B�‘ÊÃÐZfo(  Í Ó `Ae‰­ÑõÚ¨û	äa0CƒÐ'ëUpèªêÐ ± þ� $Äé@
/¼ÿ.´I‚BˆÝôWÄH)  � ¥ © Ã Ì ñ õ û ÿ 6@dˆ¬Ðôc§±ç	¯
¶
)F6`/V¬¿�Ésée’û2  Ž Â 5Œ#ã&
'
(
)
CDE[\»_›œ�ÞŠòóP�«¾èPQÜòóÁÂÃFG ä5aä
*
÷
]Jožß‹lìôR—°QîùRµ g¾?Ö	-<efŸÏÝÕÿ™‘¾ç–É å 6­\7@Ù'x
+
�ÓKižMQßïS�<@ "òH¤4
Ñ
p˜±‡Rã#Žú! å�Ub—å™˜
Ä
ø
?^«ŸàŒ˜m‹í@FõSt\Lª¶Q “ ÇšÏ”Ç=ó_g ÐÖš’â» - Ÿ ;7Üú*¶hn@¿Ë `ô6ˆ�	×	‹Ê‘f€ÿceÚ#8.<?¦Í9 àõt<¿j¿þ.­ƒJVÞE è—Ê# Ko“·Ûÿ#o®Õ‚
‘Ú†¦j¢±z¡'Ëdù
”R¬àiý—ž! æ ES]/A(ú*	`	f	N
l
v
æ
|ÔL[ƒ"=’ÅfP¡T/�¼ [ v ,8ÚyK
[
Š
±¸Œª]c´‡NÊî ~�Dw= 7r	

,
h¢Âú…ÍáN»tŸ‚6Æð³YA — é›´}›·ëŒ‘`
�
á
s¿»Â\ã[$û #íÆ|5
~
Gq|SÉÜ“  ü‘!FI_¥V
Ò
™m™>&ˆêNœæD�¨ÝæJÇ óhN’
m™²É;äŸu �’—UŸÏ™
 �™€Aÿu‘ðÍW¡ö« '‚µ½å°	D
Œî˜öâ-"ŠÓ×¹Rdz æå!V˜PæËcÌù
þ
@nGoF¨À–žM* eiŸ©Ei�±ÕùÍcÐfšw	”
©
Å
Ù
_gŸ¬½$>áTa›2]x·$‘  ‡¼ÇÍÛnØ›
¶ÐØöý•È>Kô!¡WLëV“;ÁY á�6ÏÕ1äéî)�›Îž‡×¨4~ã  ” ”Gª÷›Ç[Üñ+`uŠ’Ñ4z
YŽ›V¼( ™²+Èï]±áGJq�¤æ		R	µ	¸	Ëú
¢ñ†ÄöHhnžò†5K()   ~­<8+‹O·ciou{Š AtÑàõ	£	Á	‡æ™qmv±l<=Ì Ô[âÑš	
#¨º1öm˜»‰2Ý ôœGc£À�ø¸ô . Ýûs¾àÿ¡	&Ç8w>8/%"  ¸Aõ7Cav‰üÞWð5MVF	Ž	¢°Ø×= f¨9/ÎsªP f Y}¡Åé1XªckŒ¥X2ÚøÔc j aØþ(Ø	ŽË-gÙdçðPÛÿw@§Œ÷Ôë:D cmËµÄ^	¶Y’�$6=N‘� 3�ž	Å/ä„Oå*ta­éau�3 ? † ¥ÀÁèd)­&¬,µ¼¯¦+ 3 n�œáïöè="	Åÿ1ºùQ‚Þé;CKW\j€­¾ß¿a9®?G\wƒË  ƒNuþ=k‚™ÀüéU	 	ª	áö®R“FÏcr€˜Ó5 UÈã]lë
ò
%mw‡k¢®Ó;L_(j˜ˆŸ   8 ƒZp·1t”±ÿƒ
’fã(œ(h‚#.Œ·­m]# Lp”¸ÍÜñ $” Ö•	¿
Û§|•ðÌ¯ÍeèúcÙ¾»T,+  A Ax{µÂÅÈË@—¤¯ÌJ	î	¼
!„#£²Êî	{ÈOR • ¤SÖáôþÖ# ìxTa0Bœ«ç)€û+	7	=	g	Ê	¢
NðM²#ä>g¢^½Mï"  ê /Ln®óFþ	

F
m
È
}Õ„ÀËõù“† 0‚ î ~)
O
w
€E\¾ˆÆïk˜QU ç †Â”²^•[	a	|	ç
µ’/Å`Ö|¨ w ˆ ¥­¢«	$9KÛ¼»	\
v²Uô4L2^¸ˆs}Ëïx \ Ö �d•¤øµ$ÞhE„ S€$
2
O¹êÐ O!‚c³”›>  §³ò(²*-Ézd	p	‹	
L
‹
§
"„«Å¯ YÕ,ôä± 1 = ËÙ)ú&ÖòaÃi£Ãôû+P¼ô<u}72ZB „ Iz	

!“†Ž�Îšf±l Ð /8‰Â	­	-
áâO€IV¤ÇÙÊf¥Û ª¿IÙ	�÷’1	s	ˆ	²	§pþ ƒÒñÅ´in$ xÏçLÝ=œÜ’ÃÂa
Ž
Ì
â
:'¶Àsû³ìYèKX\üIÙ ê#Pœµh� í		$	AQÆ]ä-%Ù ˜ ÄC~¸ÍÅ	¬
û
º;bipüqŽÀíë°«$ 5 øhk†ì¸iŠM	/
tÇ�ÓäYk|¼ÃhÂÛ^£ì D O p1XÇÒ	6
r}¦£òA Ú ºÔÞ	¼È—ÊÈ¸Ýê $Hl�´Øü Q 
H3j¼@ Ýh”Í î‡í}	4	X	…	›¡TD%§… ˜êJ¦ã	Ü
S'‰ëÞE Ò ’ñ	W
Ó
šã‚AôTç©'y 4ãý‡‹"`Ã¦èBZ.nšÝU‰ë–¯HOªÈrçíO !ñG£?½&>˜—
ª?EžÔ�L˜�ÞKÈ , ô:_i™ÎýIU^d;Ì8! RÔJ
k
‰
 {Áù¥„ÌàM~‚!³ºÊ<cs	�É} Cv èûšgšêMà
=lÁéåCžIÆ$ hŒ‘ž&DhŒ°ÔøOTäbežËÎv	¯	“
þ`nšá1‰ÒV• y$ †“˜±Æà©ö5Q	´	š
0µÊãèõ¡ŽšÃÍÛG�†3ñ…§êXJ ¬ÓZŠáÐþ Ðß¢	§¹7v°¢;º<÷ l`VU©E	b¡¯×Ö<Ùþ5÷�ÓO  m‚Ž¤ç�˜û©	Àçã%�èBä ’ sÎ»`­¬qt‚" TÌ¶0?s“\ê
$l{ïÇÒKÌb‹Ÿ£ØºóSÕ+ KÁmò›ªæ”<	E
Ç
±ã.î_Õ{ ¬')»Š	N3K÷#XÔ|ó°“š  (.ƒ©¾Øù%Õ`	0	y	¬	±	¦o�™HUý|eÉÄe¤hk" wÎæ"Kg…<BÛ·ÂÌhì«
ú
&@ro²ûXp{�,Á N Gk�³×ûPŸÓW†ì3	W	
»–¢Ç·é  Âç¼–
Û
A©ÜT•�ÓG©—N& gç%f™éQ˜Ód�ÊÍu	ÿ
øHcÑŸÅ7( l…£«Å‰¨4Ïú¨ÞD	P	/a ®´¿ôÖâ¦¸;Fç6ý24I¹öpN JS×r~’[x	Æ
Mk°a{^{ÈÔ£’# M fFjŽ²ÖúÒAeÁ…¶»Ògœë•
ª
Ú
	%?Wbzœ%¶è@ DEFGHIQRjk ¡¢ª§ÎÏÐÑdÔÕÖ}ÌÍÎ„´µÑù›§Ý.`hij­¾ó:UVúûü3`yz¸ôõ  .|  qGACNNNNNNGTC,CCAGGCCTGG,GATCCGGATC,CCWGGTACCWGG,CCANNNNNTGG,CCAGGNNNTGG,CCANNNCCTGG,CCAGGNCCTGG,GCACNNNAACGTTNNNGTGC,CACNNNGTG,CCNNNNNNNGG,AACNAACRYGTGCGTGC,GCACGCACRYGTTNGTT,GCACNAACRYGTTNGTGC,AACGCACRYGTGCGTT,GACNNNNNGTC,GAANNNNNNNTTGG,CCAANNNNNNNTTC,CACNNNNGTG,AACACNNNNGTGC,GCACNNNNGTGTT,GCANNNNNNTGC,GAACNNNNNNTCC,GGANNNNNNGTTC,CAGNNNCTG,CCAGGNNCTG,CAGNNCCTGG,CCWGGGCCC,GGGCCCWGG,CCWGGGCCCWGG,AACNNNNNNGTGCACNNNNNNGTT,GACNNNGTC,GAANNNNTTC,CCWGGTACC,GGTACCWGG,CCWGGWCCWGG,ACNNNNGTAYC,GRTACNNNNGT,CCWGGYRCCWGG,GAAGNNNNNNTAC,GTANNNNNNCTTC,AACGGCNNNGTGC,GCACNNNGCCGTT,GCACGGCNNNGTT,AACNNNGCCGTGC,CGANNNNNNTGC,GCANNNNNNTCG,CGATCNNNNTGC,GCANNNNGATCG,TGANNNNNNTCA,TGATCNNNNTCA,TGANNNNGATCA,TGATCNNGATCA,AACCTGCNNGTGC,GCACNNGCAGGTT,GCACCTGCNNGTT,AACNNGCAGGTGC,GCCNNNNNGGC,AACNNNNNNGTGCMC,GKGCACNNNNNNGTT,CCWGGNCCWGG,AACTGGGNNGTGC,GCACNNCCCAGTT,GCACTGGGNNGTT,AACNNCCCAGTGC,GACNNNNGTC,GAGNNNNNCTC,CCWGGTCTC,GAGACCWGG,GATNNNNATC,GATCNNNATC,GATNNNGATC,GATCNNGATC,CCWGGCGCCWGG,ACNNNNNCTCC,GGAGNNNNNGT,AACNNNNNNGTGCAG,CTGCACNNNNNNGTT,GATCATGATC,CCWGGNNCCWGG,AACTGGNNNGTGC,GCACNNNCCAGTT,GCACTGGNNNGTT,AACNNNCCAGTGC,AACNAACCGGTGCGTGC,GCACGCACCGGTTNGTT,GCACNAACCGGTTNGTGC,AACGCACCGGTGCGTT,GCANNNNNTGC,GCACNNNNNNGTTCGAACNNNNNNGTGC,CCTNNNNNAGG,GCNNNNNNNGC,CCANNNNNNTGG,CCAGGNNCCTGG,CCTGGCCAGG,CAANNNNNGTGG,CCACNNNNNTTG,TTTAAACNNNNNNGTGC,GCACNNNNNNGTTTAAA,GCACNNNNNNGTTTAAACNNNNNNGTGC,CCAGGNCCY,RGGNCCTGG,CCWGGGNCCTGG,CCAGGNCCCWGG,AAGNNNNNCTT,GAYNNNNNVTC,GABNNNNNRTC,GAYNNNNNRTC,GATCNNNNVTC,GABNNNNGATC,GAYNNNNGATC,GATCNNNNRTC,GATCNNNGATC,GTYAACNNNNNNGTGC,GCACNNNNNNGTTRAC,GCACNNNNNNGTTAACNNNNNNGTGC,GATCNGATC,TAACTATAACGGTCCTAAGGTAGCGA,TCGCTACCTTAGGACCGTTATAGTTA,CTCTCTTAAGGTAGC,GCTACCTTAAGAGAG,TAGGGATAACAGGGTAAT,ATTACCCTGTTATCCCTA,GTTAACNNNNNNGTGC,GCACNNNNNNGTTAAC,AACNAACGCGTGCGTGC,GCACGCACGCGTTNGTT,GCACNAACGCGTTNGTGC,AACGCACGCGTGCGTT,TCCAACNNNNNNGTGC,GCACNNNNNNGTTGGA,CAYNNNNRTG,AACAYNNNNGTGC,GCACNNNNRTGTT,GTTTAAACNNNNNNGTGC,GCACNNNNNNGTTTAAAC,CCWGGCGCC,GGCGCCWGG,CCWGGNNCC,GGNNCCWGG,GATCGCGATC,AACNAACATGTGCGTGC,GCACGCACATGTTNGTT,GCACNAACATGTTNGTGC,AACGCACATGTGCGTT,TGGCAAACAGCTATTATGGGTATTATGGGT,ACCCATAATACCCATAATAGCTGTTTGCCA,ATCTATGTCGGGTGCGGAGAAAGAGGTAATGAAATGG,CCATTTCATTACCTCTTTCTCCGCACCCGACATAGAT,AACNNGCACGTGCNNGTT,GAACNNNNNCTC,GAGNNNNNGTTC,CCAGGWCCY,RGGWCCTGG,CCWGGGWCCTGG,CCAGGWCCCWGG,CCAGGWCCTGG,TTATAACNNNNNNGTGC,GCACNNNNNNGTTATAA,GCACNNNNNNGTTATAACNNNNNNGTGC,GAACNNNNNNTAC,GTANNNNNNGTTC,GGCCNNNNNGGCC,AACNNACTAGTGC,GCACTAGTNNGTT,AACTAGTNNGTGC,GCACNNACTAGTT,AACNAACTAGTGCGTGC,GCACGCACTAGTTNGTT,GCACNAACTAGTTNGTGC,AACGCACTAGTGCGTT,AACNNNAACGTGCNNGTGC,GCACNNGCACGTTNNNGTT,GCACCCANNNGTT,AACNNNTGGGTGC,TTAACNNNNNNGTGC,GCACNNNNNNGTTAA,CACNNNNNNTCC,GGANNNNNNGTG,CACNNNNGATCC,GGATCNNNNGTG,GATCTAGATC,CCANNNNNNNNNTGG,CCAGGCCT,AGGCCTGG,CCTCGAGG,GATCCGGA,TCCGGATC,GGCGCGCC,GCGATCGC,CCWGGWCC,GGWCCWGG,GATCGATC,GATCATGA,TCATGATC,GCGGCCGC,CCTGGCCR,YGGCCAGG,CCWGGNCC,GGNCCWGG,GGCCGGCC,RTGCGCAY,GATCNNGA,TCNNGATC,CGCGCGCG,CCTGGCCA,TGGCCAGG,CGCCGGCG,GTTTAAAC,GATCGCGA,TCGCGATC,TTAATTAA,VCTCGAGB,CCTGCAGG,CRCCGGYG,CGTCGACG,ATTTAAAT,GCCCGGGC,GATCTAGA,TCTAGATC,CACCTGC,GCAGGTG,CCTNAGG,GATCGAT,ATCGATC,CCTCAGC,GCTGAGG,GCTNAGC,CCTNAGC,GCTNAGG,GCTCTTC,GAAGAGC,GGTNACC,CGGWCCG,ACCWGGT,RGGNCCY,CCTGGAG,CTCCAGG,GGTGATC,GATCACC,GATCNGA,TCNGATC,GGGWCCC,GAAGATC,GATCTTC,CCCWGGG,TCCNGGA,TCCWGGA,RGGWCCY,TTATAA,AGGCCT,GACGTC,GTMKAC,TCCGGA,TGCGCA,ACCTGC,GCAGGT,GGTACC,AGTACT,GGYRCC,CCGCTC,GAGCGG,AACGTT,YGGCCR,RAATTY,CTGAAG,CTTCAG,CACGTG,GRCGYC,AGCGCT,CTTAAG,ACRYGT,ACCGGT,ACTAGT,CACGTC,GACGTG,GWGCWC,GTGCAC,CYCGRG,GGGCCC,ATTAAT,CCTAGG,TTCGAA,GCTAGC,GKGCMC,TGGCCA,GGATCC,GRGCYC,ATCGAT,CACGAG,CTCGTG,GGCGCC,GAAGAC,GTCTTC,GCATGC,GTATCC,GGATAC,TGATCA,ACTGGG,CCCAGT,CTRYAG,RGCGCY,AGATCT,GGNNCC,CTGGAG,CTCCAG,CTTGAG,CTCAAG,CGATCG,GGTCTC,GAGACC,YACGTR,CCNNGG,GAATGC,GCATTC,WCCGGW,GCAATG,CATTGC,RCCGGY,GCGCGC,GAGGAG,CTCCTC,CGGCCG,CCCAGC,GCTGGG,GTGCAG,CTGCAC,CGRYCG,CGTACG,CGTCTC,GAGACG,CCATGG,TCGCGA,GDGCHC,TGTACA,TCATGA,ACATGT,GTATAC,CCWWGG,CTCTTC,GAAGAG,GCNNGC,CCRYGG,GTTAAC,RCATGY,TACGTA,RGATCY,GCGATG,CATCGC,GCAGTG,CACTGC,CCCGGG,CCGCGG,TTTAAA,GGCGGA,TCCGCC,GAGCTC,GATATC,CTGRAG,CTYCAG,CAGCAG,CTGCTG,GAATTC,ATGCAT,CATATG,GTYRAC,AAGCTT,GTNNAC,TCNNGA,CAATTG,ACGCGT,TCCRAC,GTYGGA,GCCGGC,CMGCKG,GCCGAG,CTCGGC,CTCGAG,CTGCAG,CAGCTG,GTCGAC,CTYRAG,AATATT,GATCGA,TCGATC,GACCGA,CACCCA,TCGGTC,TGGGTG,WGTACW,TARCCA,TGGYTA,TCTAGA,GGATC,GATCC,CCWGG,GTCTC,GAGAC,GCWGC,GGNCC,CCSGG,GGTGA,TCACC,GGWCC,GCAGC,GCTGC,CCATC,GATGG,ACGGC,GCCGT,GCNGC,CCNGG,GCATC,GATGC,ACTGG,CCAGT,GGATG,CATCC,CTCAG,CTGAG,GGGAC,GTCCC,ACNGT,CTNAG,CAGTG,CACTG,GACGC,GCGTC,CCCGC,GCGGG,GANTC,CGWCG,TCNGA,CCTTC,GAAGG,GTNAC,GAAGA,TCTTC,GAGTC,GACTC,GTSAC,GAWTC,GCSGC,CASTG,ATGAA,TTCAT,ACGGA,TCCGT,CGCG,CCGC,GCGG,GTAC,AGCT,GCGC,CTAG,GATC,GGCC,CCGG,CATG,RGCY,YATR,ACGT,TGCA,AATT,CCTC,GAGG,TTAA,ASST,TCGA                                        *                                                                                                                                                                                                                                                                                                                   $                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
                    	                                                  
                                     #                                                                                              !                	                                                                                                                                                                      "                              
      ;   &                  	                  
                                       
            
                               %   	      %         '   $      z   S   "             #       d                     *                                                                                                                                                 $                                                                                                                                                                                                                                                                                                                      
        	                  
             #                                    !      	                                                              "          
  ; &      	      
             
    
           % 	  %   ' $  z S "     #   d   râ  t  t4  tf  xŒ  }|  ƒÎ 	w»&¥jklmªÅÆàægÁÕÐ„…¼œ»ÍÞy	•
–
Æ
Û
A®¯Ê	
ÇÙ–<‚Ç/ˆ	pn¯ÿR�Ï	‡8ññÄ	$è¦™ÆÆ0—o	ür$æA+ 7 �»ú$ÁàßèzC	Ÿ	z¹×»J¥ÌN±Ý1tæ"¦1Lvx™·NÄÇn	 
ÿ/yä	3Ç 
ÿ/Ç 
ÿ/3Šˆ	O,Ë2Òâjpµ#ûÏ5±	Î<ô6h†ê9h²	Ä³	#	#	<¥P”äé
0”ÉIwŠoŒ¡AšÛS%ååò	("éÇ�™¤
›yL›åyŽ�çS	· ÏŽ�ŒÒër{8ÖŠ+ÐÞïÿ&]	H¸(â 
äïh í		ÆÞúLüÉçS	Lûª·0Ñ	tÜ\�F ñzÏ�FñÏ…«Å:‰Þ´Îô1J¬ æÑßWÈ1�F�J±ñÏÿ&Hâ‰\1QJð ñadÌLçS	©¶E¤Tdv5ˆË
a5 î¸itÀ%…šLçS	ß¸÷9«=EŠL›â1Ðåy”ÊRŽ²â�¥çS	Jï·Õü ^‡Z¨Ïäðx‰'R!< £¸�
wúîi£¨ST…†Å(`§W˜ÕªÂæ[»ß¢	š
.k´óô%&r²WOsPR1
’ßç�™…W(j °õ³	ÉÂÚ„N2ObËÁúçG	àÝÇ`£8¸f »‰È\1�FQ�J±ð ñzÏñÆ	‡wª·Wªæ»=IÆ^}°·¤>f„ÇvÂÉüóTµOJNæpÆë¢:HÀÔØ2(`Õ»OÙ	‡ ¤¡ªT·â‰8C™¥¥¶œ«¾
½-
âÙ…Å´ô¶
¬¿sÿ‘Í\ Cxh í		Æ‰ÞxÅÈ¼
O hÃ¢R_	Ù	å
 ?c«ÏóBg¼D�FX_	Í	Ù	å
.]ñÙÏct«µô!6Iˆ›¥h*	`
L†=�™ó &ˆê=‡ŠwŸu-z0j	°ÉÌJ	î ­Ö¡	¯:5 itJ	Ö:R!'< ²
FVØÚøl9:�Ò“ _šýÆ	
eø	ÍÝâ‰‰8™¥ã�îD¦v·TwÎæK<ÛÂ\ê
$l&r²ÒKX‘
tw4 @ wz´÷ÇÊjË‰I	L	í	 ƒÆ €XjNQgÕ]¢ë•d12?•Ê~²¥¦	JKå^­¾œ¡Â…†ÅÆ¨4P	š
/´µôõF2êI¥Pƒ\ÿr	Ÿ‚ð³•å¾œ@ wz´ÇÊËI	í	 ƒNQÕ4 ÷j‰L	Æ €Xjg]¢ë')Š	XÔó° �ž*\àFp£å	�'_ÕÒ4 @ wz�´÷ÇÊjæËî€°I‰Ž	I	L	¨	·	í	 ƒÆù 	€ð…õ$Xjmã~NQgºÕ4]s�¢ëT…†ÅÆwÎæK¨4<ÛÂ\P	š
ê
$/l´µôõ&rF²ÒKX2êI¦²ñ±
ƒÄ®+ã( nÔ!ýÜË
9JWÌ{ïÌbØºS+XmÖÓœ å§³É§
" ÕôÔ¥Êc	Pœ$	%=¾o ÚÅž
dÌÏ¼=�ðFkÃT”	Za”‘Ø®çê�ªPœÔ$	¥Êc	%Lp”¸Ü $ ¿
Ûeúc¾,Â-
âOIVÙ„ ü 	_ÊµXMŽl£ú¿âçp»m×J :À3B`i
=¿+:Sž*/aw_ûs¡	&’�6=%éo›´ŒŸÏ‚
‘'uÖ\ã¡¬$â ¼–
©�Ó—ÑŒjv¢ï	Aª%²b +Ù¦QWú	¡ÝB[Ïê5oÄXd % ^z©³¶Ï©A* F>œ�ÝJÇ3B*a`i
¿S/w_b ¦QW¡Ý5X=+:ž�æî€°IŽ	¨	·	ù	ð…õ$mã~º4s�Lp”¸Ü $Â -
¿
ÛâOIVeúc¾Ù,# \9w¸7ÙxM<(3Uö3�ž	Å/ä„Oå*ta­éau�3cm‚Ž¤ç�˜û©	Àçã%�èBä ’ sÎ»`­¬qt‚  »mŽÎî°IŽÔ	·	×íùÆ	ð…ðõJ *mt‰y	�4}:UÀg DœzÞÚ—	Ç	B ]˜¡žˆ		K	Ã	ï	‡
´gÆ|^¸æçðT“ÿ ×›M<2ŒèT	Ÿ	à0¹¬øNPÝ:[i¬¾+´b®>F`vŒ¥24D O p1XÇÒ	6
r}¦£òAÞrÚãø:Š�lø�Šî9DLš¦dv¤¦·Û¹#,Ñ.eƒßô2?ð–Ê '^²ê¥È	:	§	KImÅÐâ”^®¹¡Ã)†“˜±Æà©ö5Q	´	š
0µÊãèõ¡ŽšÃÍÛG�†3ñ…§êXJw ˆ ¥­¢«	$9KÛ¼»	\
v²Uô4L2^¸ˆs}ËïxB BO€Š¯Ã#,]ÌÑ.N^eƒ˜¥ßåô2?¡ð÷Kf–Ê 'R^ž²âê$ˆ¥ÀÈ				:	B	K	§	Ã	ï	‡
",KXy¸Ìñû,9£´ÔIm‡¤Ëg›°Æi|ÅÐâü^¸æëS”ŸÊçR^‡¡¥®ðJT“¹ÿ¡ò ¡Ã×)\ w ˆ › È Ö ÷ %8[£Ç3R”¡¥­V …¢«ý	$9KÛ¼»	ó	\
Õ
UIVXZ\vƒŽ²ÎU�ô4L2^d•¤¸øAµrˆÐÒÔ$Gs}ËÑÞï1hEx„)e i bX| Äè0u×´û'ÃÝï]	j¤,v‹r~©C 6 �£vÆžGj¯H	ì	0
ð
uS‚Ná	òiÃ„ÜÐí€ ¯ ã ï ^
e
x
4†]x‰Ô°âáËåðgç%f™éQ˜Ód�ÊÍu	ÿ
øHcÑŸÅ7¡ ;9,ž/¸Opv|‹!BÆá	&	€	¤	”Ìç'*nþOÍTI l ­ ½ ¼Ú	°
·
”›xWçÒy­²ÀõàtÖáíø	kz÷B e i ¢ bÓX| Äè0:]žJu˜×;z¡´Úäû
'x¹ÃÝDž¤ï‚ˆ		'	2	K	]	t	Ã	ï	‡
ì
&n¨j¤´è,CqgÆú|+^Œ¸Ä×æoÒçv¡ðT“‹Æÿr~©Î ×C- Ÿ ;7Üú*¶hn@¿Ë   -<AlignableSequences trimStringency="Medium"/>  !<AdditionalSequenceProperties><UpstreamStickiness>0</UpstreamStickiness><DownstreamStickiness>0</DownstreamStickiness><UpstreamModification>FivePrimePhosphorylated</UpstreamModification><DownstreamModification>FivePrimePhosphorylated</DownstreamModification></AdditionalSequenceProperties>
  /v<?xml version="1.0"?><Features nextValidID="22"><Feature recentID="0" name="M13 rev" directionality="2" type="primer_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="3939-3955" color="#a020f0" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;common sequencing primer, one of multiple similar variants&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="1" name="M13 fwd" directionality="1" type="primer_bind" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="6688-6704" color="#a020f0" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;common sequencing primer, one of multiple similar variants&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="2" name="IRES" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1240-1791" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;internal ribosome entry site (IRES) of the encephalomyocarditis virus (EMCV)&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="3" name="TRE3GV promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="574-923" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;3rd-generation Tet-responsive promoter that can be activated by binding of Tet-OnÂ® 3G, optimized for retroviral and lentiviral vectors&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="4" name="SV40 poly(A) signal" type="polyA_signal" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2530-2651" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 polyadenylation signal&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="5" name="mCherry" directionality="1" translationMW="26722.72" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" hitsStopCodon="1"><Segment range="1803-2513" color="#ff0000" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;mammalian codon-optimized&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;monomeric derivative of DsRed fluorescent protein (&lt;a href=&quot;http://www.ncbi.nlm.nih.gov/pubmed/15558047&quot; title=&quot;http://www.ncbi.nlm.nih.gov/pubmed/15558047&quot;&gt;Shaner et al., 2004&lt;/a&gt;)&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="translation"><V text="MVSKGEEDNMAIIKEFMRFKVHMEGSVNGHEFEIEGEGEGRPYEGTQTAKLKVTKGGPLPFAWDILSPQFMYGSKAYVKHPADIPDYLKLSFPEGFKWERVMNFEDGGVVTVTQDSSLQDGEFIYKVKLRGTNFPSDGPVMQKKTMGWEASSERMYPEDGALKGEIKQRLKLKDGGHYDAEVKTTYKAKKPVQLPGAYNVNIKLDITSHNEDYTIVEQYERAEGRHSTGGMDELYK*"/></Q></Feature><Feature recentID="6" name="f1 ori" directionality="2" type="rep_origin" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="6091-6546" color="#ffff00" type="standard"/><Q name="direction"><V text="LEFT"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;f1 bacteriophage origin of replication; arrow indicates direction of (+) strand synthesis&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="7" name="ori" directionality="2" type="rep_origin" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4341-4929" color="#ffff00" type="standard"/><Q name="direction"><V text="LEFT"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;high-copy-number ColE1/pMB1/pBR322/pUC origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="8" name="tet operator" type="protein_bind" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="798-816" color="#31849b" type="standard"/><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;tetracycline repressor TetR&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;tetO&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;bacterial operator O&lt;sub&gt;2&lt;/sub&gt; for the &lt;i&gt;tetR&lt;/i&gt; and &lt;i&gt;tetA&lt;/i&gt; genes&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="9" name="tet operator" type="protein_bind" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="762-780" color="#31849b" type="standard"/><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;tetracycline repressor TetR&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;tetO&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;bacterial operator O&lt;sub&gt;2&lt;/sub&gt; for the &lt;i&gt;tetR&lt;/i&gt; and &lt;i&gt;tetA&lt;/i&gt; genes&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="10" name="tet operator" type="protein_bind" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="726-744" color="#31849b" type="standard"/><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;tetracycline repressor TetR&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;tetO&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;bacterial operator O&lt;sub&gt;2&lt;/sub&gt; for the &lt;i&gt;tetR&lt;/i&gt; and &lt;i&gt;tetA&lt;/i&gt; genes&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="11" name="tet operator" type="protein_bind" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="690-708" color="#31849b" type="standard"/><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;tetracycline repressor TetR&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;tetO&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;bacterial operator O&lt;sub&gt;2&lt;/sub&gt; for the &lt;i&gt;tetR&lt;/i&gt; and &lt;i&gt;tetA&lt;/i&gt; genes&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="12" name="tet operator" type="protein_bind" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="654-672" color="#31849b" type="standard"/><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;tetracycline repressor TetR&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;tetO&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;bacterial operator O&lt;sub&gt;2&lt;/sub&gt; for the &lt;i&gt;tetR&lt;/i&gt; and &lt;i&gt;tetA&lt;/i&gt; genes&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="13" name="tet operator" type="protein_bind" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="618-636" color="#31849b" type="standard"/><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;tetracycline repressor TetR&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;tetO&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;bacterial operator O&lt;sub&gt;2&lt;/sub&gt; for the &lt;i&gt;tetR&lt;/i&gt; and &lt;i&gt;tetA&lt;/i&gt; genes&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="14" name="tet operator" type="protein_bind" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="582-600" color="#31849b" type="standard"/><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;tetracycline repressor TetR&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;tetO&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;bacterial operator O&lt;sub&gt;2&lt;/sub&gt; for the &lt;i&gt;tetR&lt;/i&gt; and &lt;i&gt;tetA&lt;/i&gt; genes&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="15" name="lac operator" type="protein_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="3963-3979" color="#31849b" type="standard"/><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;lac&lt;/i&gt; repressor encoded by &lt;i&gt;lacI&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;The &lt;i&gt;lac&lt;/i&gt; repressor binds to the &lt;i&gt;lac&lt;/i&gt; operator to inhibit transcription in &lt;i&gt;E. coli&lt;/i&gt;. This inhibition can be relieved by adding lactose or isopropyl-Î²-D-thiogalactopyranoside (IPTG).&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="16" name="CAP binding site" type="protein_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4032-4053" color="#31849b" type="standard"/><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;E. coli&lt;/i&gt; catabolite activator protein&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;CAP binding activates transcription in the presence of cAMP.&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="17" name="lac promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment name="-10" range="3987-3993" color="#ffffff" type="standard"/><Segment range="3994-4011" color="#ffffff" type="standard"/><Segment name="-35" range="4012-4017" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;promoter for the &lt;i&gt;E. coli lac&lt;/i&gt; operon&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="18" name="AmpR" directionality="2" translationMW="31558.16" type="CDS" swappedSegmentNumbering="1" allowSegmentOverlaps="0" cleavageArrows="5891" readingFrame="-1" consecutiveTranslationNumbering="1" hitsStopCodon="1" detectionMode="exactProteinMatch"><Segment range="5100-5891" color="#ccffcc" type="standard" translated="1"/><Segment name="signal sequence" range="5892-5960" color="#ccffcc" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to ampicillin, carbenicillin, and related antibiotics&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;Î²-lactamase&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="translation"><V text="MSIQHFRVALIPFFAAFCLPVFA,HPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRIDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPVAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW*"/></Q></Feature><Feature recentID="19" name="AmpR promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="5961-6065" color="#ffffff" type="standard"/><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="20" name="piggyBac left (5') inverted repeat" type="repeat_region" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" originalSequence="CCCTAGAAAGATAGTCTGCGTAAAATTGACGCATG"><Segment range="3414-3448" color="#ffcc99" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;piggyBac transposon-specific inverted terminal repeat sequence (ITR)&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="21" name="piggyBac right (3') inverted repeat" type="repeat_region" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" originalSequence="CCCTAGAAAGATAATCATATTGTGACGTACGTTAAAGATAATCATGCGTAAAATTGACGCATG"><Segment range="78-140" color="#ffcc99" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;&lt;!--StartFragment--&gt;piggyBac transposon-specific inverted terminal repeat sequence (ITR)&lt;!--EndFragment--&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature></Features>
  !¾<?xml version="1.0"?><Primers nextValidID="16"><HybridizationParams minContinuousMatchLen="10" allowMismatch="1" minMeltingTemperature="40"/><Primer recentID="0" name="Amp-R" sequence="ATAATACCGCGCCACATAGC" description="Ampicillin resistance gene, reverse primer"><BindingSite location="5722-5741" boundStrand="0" annealedBases="ATAATACCGCGCCACATAGC" meltingTemperature="58"><Component hybridizedRange="5722-5741" bases="ATAATACCGCGCCACATAGC"/></BindingSite><BindingSite simplified="1" location="5722-5741" boundStrand="0" annealedBases="ATAATACCGCGCCACATAGC" meltingTemperature="58"><Component hybridizedRange="5722-5741" bases="ATAATACCGCGCCACATAGC"/></BindingSite></Primer><Primer recentID="1" name="EBV-rev" sequence="GTGGTTTGTCCAAACTCATC" description="SV40 polyA terminator, reverse primer"><BindingSite location="2620-2639" boundStrand="0" annealedBases="GTGGTTTGTCCAAACTCATC" meltingTemperature="55"><Component hybridizedRange="2620-2639" bases="GTGGTTTGTCCAAACTCATC"/></BindingSite><BindingSite simplified="1" location="2620-2639" boundStrand="0" annealedBases="GTGGTTTGTCCAAACTCATC" meltingTemperature="55"><Component hybridizedRange="2620-2639" bases="GTGGTTTGTCCAAACTCATC"/></BindingSite></Primer><Primer recentID="2" name="F1ori-F" sequence="GTGGACTCTTGTTCCAAACTGG" description="F1 origin, forward primer"><BindingSite location="6227-6248" boundStrand="1" annealedBases="GTGGACTCTTGTTCCAAACTGG" meltingTemperature="57"><Component hybridizedRange="6227-6248" bases="GTGGACTCTTGTTCCAAACTGG"/></BindingSite><BindingSite simplified="1" location="6227-6248" boundStrand="1" annealedBases="GTGGACTCTTGTTCCAAACTGG" meltingTemperature="57"><Component hybridizedRange="6227-6248" bases="GTGGACTCTTGTTCCAAACTGG"/></BindingSite></Primer><Primer recentID="3" name="F1ori-R" sequence="AGGGAAGAAAGCGAAAGGAG" description="F1 origin, reverse primer"><BindingSite location="6439-6458" boundStrand="0" annealedBases="AGGGAAGAAAGCGAAAGGAG" meltingTemperature="57"><Component hybridizedRange="6439-6458" bases="AGGGAAGAAAGCGAAAGGAG"/></BindingSite><BindingSite simplified="1" location="6439-6458" boundStrand="0" annealedBases="AGGGAAGAAAGCGAAAGGAG" meltingTemperature="57"><Component hybridizedRange="6439-6458" bases="AGGGAAGAAAGCGAAAGGAG"/></BindingSite></Primer><Primer recentID="4" name="IRES reverse" sequence="GCATTCCTTTGGCGAGAG" description="IRES internal ribosome entry site, reverse primer. Also called pCDH-rev"><BindingSite location="1383-1400" boundStrand="1" annealedBases="GCATTCCTTTGGCGAGAG" meltingTemperature="57"><Component hybridizedRange="1383-1400" bases="GCATTCCTTTGGCGAGAG"/></BindingSite><BindingSite simplified="1" location="1383-1400" boundStrand="1" annealedBases="GCATTCCTTTGGCGAGAG" meltingTemperature="57"><Component hybridizedRange="1383-1400" bases="GCATTCCTTTGGCGAGAG"/></BindingSite></Primer><Primer recentID="5" name="IRES-F" sequence="TGGCTCTCCTCAAGCGTATT" description="IRES internal ribosome entry site, forward primer"><BindingSite location="1610-1629" boundStrand="0" annealedBases="TGGCTCTCCTCAAGCGTATT" meltingTemperature="58"><Component hybridizedRange="1610-1629" bases="TGGCTCTCCTCAAGCGTATT"/></BindingSite><BindingSite simplified="1" location="1610-1629" boundStrand="0" annealedBases="TGGCTCTCCTCAAGCGTATT" meltingTemperature="58"><Component hybridizedRange="1610-1629" bases="TGGCTCTCCTCAAGCGTATT"/></BindingSite></Primer><Primer recentID="6" name="L4440" sequence="AGCGAGTCAGTGAGCGAG" description="L4440 vector, forward primer"><BindingSite location="4169-4186" boundStrand="1" annealedBases="AGCGAGTCAGTGAGCGAG" meltingTemperature="58"><Component hybridizedRange="4169-4186" bases="AGCGAGTCAGTGAGCGAG"/></BindingSite><BindingSite simplified="1" location="4169-4186" boundStrand="1" annealedBases="AGCGAGTCAGTGAGCGAG" meltingTemperature="58"><Component hybridizedRange="4169-4186" bases="AGCGAGTCAGTGAGCGAG"/></BindingSite></Primer><Primer recentID="7" name="LNCX" sequence="AGCTCGTTTAGTGAACCGTCAGATC" description="Human CMV promoter, forward primer"><BindingSite location="861-885" boundStrand="0" annealedBases="AGCTCGTTTAGTGAACCGTCAGATC" meltingTemperature="60"><Component hybridizedRange="861-885" bases="AGCTCGTTTAGTGAACCGTCAGATC"/></BindingSite><BindingSite simplified="1" location="861-885" boundStrand="0" annealedBases="AGCTCGTTTAGTGAACCGTCAGATC" meltingTemperature="60"><Component hybridizedRange="861-885" bases="AGCTCGTTTAGTGAACCGTCAGATC"/></BindingSite></Primer><Primer recentID="8" name="M13 Forward" sequence="TGTAAAACGACGGCCAGT" description="In lacZ gene. Also called M13-F20 or M13 (-21) Forward"><BindingSite location="6686-6703" boundStrand="0" annealedBases="TGTAAAACGACGGCCAGT" meltingTemperature="57"><Component hybridizedRange="6686-6703" bases="TGTAAAACGACGGCCAGT"/></BindingSite><BindingSite simplified="1" location="6686-6703" boundStrand="0" annealedBases="TGTAAAACGACGGCCAGT" meltingTemperature="57"><Component hybridizedRange="6686-6703" bases="TGTAAAACGACGGCCAGT"/></BindingSite></Primer><Primer recentID="9" name="M13 Reverse" sequence="CAGGAAACAGCTATGAC" description="In lacZ gene. Also called M13-rev"><BindingSite location="3938-3954" boundStrand="1" annealedBases="CAGGAAACAGCTATGAC" meltingTemperature="49"><Component hybridizedRange="3938-3954" bases="CAGGAAACAGCTATGAC"/></BindingSite><BindingSite simplified="1" location="3938-3954" boundStrand="1" annealedBases="CAGGAAACAGCTATGAC" meltingTemperature="49"><Component hybridizedRange="3938-3954" bases="CAGGAAACAGCTATGAC"/></BindingSite></Primer><Primer recentID="10" name="M13/pUC Forward" sequence="CCCAGTCACGACGTTGTAAAACG" description="In lacZ gene"><BindingSite location="6672-6694" boundStrand="0" annealedBases="CCCAGTCACGACGTTGTAAAACG" meltingTemperature="61"><Component hybridizedRange="6672-6694" bases="CCCAGTCACGACGTTGTAAAACG"/></BindingSite><BindingSite simplified="1" location="6672-6694" boundStrand="0" annealedBases="CCCAGTCACGACGTTGTAAAACG" meltingTemperature="61"><Component hybridizedRange="6672-6694" bases="CCCAGTCACGACGTTGTAAAACG"/></BindingSite></Primer><Primer recentID="11" name="M13/pUC Reverse" sequence="AGCGGATAACAATTTCACACAGG" description="In lacZ gene"><BindingSite location="3951-3973" boundStrand="1" annealedBases="AGCGGATAACAATTTCACACAGG" meltingTemperature="58"><Component hybridizedRange="3951-3973" bases="AGCGGATAACAATTTCACACAGG"/></BindingSite><BindingSite simplified="1" location="3951-3973" boundStrand="1" annealedBases="AGCGGATAACAATTTCACACAGG" meltingTemperature="58"><Component hybridizedRange="3951-3973" bases="AGCGGATAACAATTTCACACAGG"/></BindingSite></Primer><Primer recentID="12" name="mCherry-F" sequence="CCCCGTAATGCAGAAGAAGA" description="mCherry, forward primer"><BindingSite location="2215-2234" boundStrand="0" annealedBases="CCCCGTAATGCAGAAGAAGA" meltingTemperature="54"><Component hybridizedRange="2215-2234" bases="CCCCGTAATGCAGAAGAAGA"/></BindingSite><BindingSite simplified="1" location="2215-2234" boundStrand="0" annealedBases="CCCCGTAATGCAGAAGAAGA" meltingTemperature="54"><Component hybridizedRange="2215-2234" bases="CCCCGTAATGCAGAAGAAGA"/></BindingSite></Primer><Primer recentID="13" name="mCherry-R" sequence="TTGGTCACCTTCAGCTTGG" description="mCherry, reverse primer"><BindingSite location="1947-1965" boundStrand="1" annealedBases="TTGGTCACCTTCAGCTTGG" meltingTemperature="57"><Component hybridizedRange="1947-1965" bases="TTGGTCACCTTCAGCTTGG"/></BindingSite><BindingSite simplified="1" location="1947-1965" boundStrand="1" annealedBases="TTGGTCACCTTCAGCTTGG" meltingTemperature="57"><Component hybridizedRange="1947-1965" bases="TTGGTCACCTTCAGCTTGG"/></BindingSite></Primer><Primer recentID="14" name="pBR322ori-F" sequence="GGGAAACGCCTGGTATCTTT" description="pBR322 origin, forward primer"><BindingSite location="4420-4439" boundStrand="1" annealedBases="GGGAAACGCCTGGTATCTTT" meltingTemperature="56"><Component hybridizedRange="4420-4439" bases="GGGAAACGCCTGGTATCTTT"/></BindingSite><BindingSite simplified="1" location="4420-4439" boundStrand="1" annealedBases="GGGAAACGCCTGGTATCTTT" meltingTemperature="56"><Component hybridizedRange="4420-4439" bases="GGGAAACGCCTGGTATCTTT"/></BindingSite></Primer><Primer recentID="15" name="SV40pA-R" sequence="GAAATTTGTGATGCTATTGC" description="SV40 polyA, reverse primer"><BindingSite location="2566-2585" boundStrand="1" annealedBases="GAAATTTGTGATGCTATTGC" meltingTemperature="52"><Component hybridizedRange="2566-2585" bases="GAAATTTGTGATGCTATTGC"/></BindingSite><BindingSite simplified="1" location="2566-2585" boundStrand="1" annealedBases="GAAATTTGTGATGCTATTGC" meltingTemperature="52"><Component hybridizedRange="2566-2585" bases="GAAATTTGTGATGCTATTGC"/></BindingSite></Primer></Primers>
  »<Notes>
<UUID>6453eca3-890b-41e3-a069-b6d79ec68734</UUID>
<Type>Synthetic</Type>
<ConfirmedExperimentally>0</ConfirmedExperimentally>
<CustomMapLabel>mARG1 cassette 1</CustomMapLabel>
<UseCustomMapLabel>1</UseCustomMapLabel>
<Description>Mammalian acoustic reporter gene 1 cassette 1 on the piggyBac trasposon plasmid..</Description>
<Created UTC="16:4:48">2019.11.27</Created>
<LastModified UTC="16:4:48">2019.11.27</LastModified>
<SequenceClass>UNA</SequenceClass>
<TransformedInto>unspecified</TransformedInto>
<References>
<Reference title="Ultrasound Imaging of Gene Expressing in Mammalian Cells" journal="Unpublished" type="Journal Article" journalName="Unpublished"/>
</References>
</Notes>
  Y     –         
?????                                                                                                       ÿ d      HO  d               E              ÿÿÿÿYô? P                                                                                                                                                              3<?xml version="1.0"?><EnzymeVisibilities vals=""/>
   )<?xml version="1.0"?><CustomEnzymeSets/>
